Chronic kidney disease (CKD) is a leading cause of life lost worldwide. The contribution factors to CKD progression include parenchymal cell loss, chronic inflammation, fibrosis and reduced regenerative capacity of the kidney. CKD complications such as anemia that are associated with increased risks of death ...
Chronic kidney disease (CKD) is a leading cause of life lost worldwide. The contribution factors to CKD progression include parenchymal cell loss, chronic inflammation, fibrosis and reduced regenerative capacity of the kidney. CKD complications such as anemia that are associated with increased risks of death should be promptly monitored. The prevalence and mortality of CKD are rapidly increasing, illustrating the shortcomings of current therapeutic approaches. Research aimed at identifying novel therapies for CKD is still needed to prevent disease progression.
In recent years, herbal medicine has demonstrated its potential as an alternative therapy for treatment of numerous diseases, and remains an important source for the discovery of new drugs that has attracted greater attention recently. There has also been evidence showing that herbal medicine is increasingly popular for promoting healthcare and preventing CKD. For example, Salvia miltiorrhiza, one of the most common herbs, either as a single herb or in an herbal formula, has been reported to exhibit renoprotective and antifibrosis effects in CKD rats, and the mechanisms of which are involved in regulating TGFβ/SMAD signalling and activating Nrf2 pathway. Tanshinone IIA, danshensu and salvianolic acid within S. miltiorrhiza are considered as active ingredients. Shenkang, a mixture of herbal medicine containing S. miltiorrhiza is also widely prescribed to treat CKD patients in China. Moreover, Angelica sinensis has been found to ameliorate CKD-associated anemia in rats via stimulating erythropoietin production and improving iron availability. The application of herbal medicine to control CKD by targeting its contribution factors or complications therefore can be a promising therapeutic agent in treating patients with CKD.
Kidney Failure Symptoms, Causes & Treatments
Although the mechanisms of action for certain herbal medicine have been investigated, specific target and effective therapy for CKD are still lacking. As strategies target a single pathogenic process may result in unexpected adverse effect, current therapies for CKD targeting multiple pathogenic pathway are needed to either stop or reverse progression. Multitarget effects have been generally accepted to achieve the pharmacological action of herbal medicine due to its multicompound nature within the herb. Therefore, understanding the multifunctional mechanisms of herbal medicine in retarding CKD progression may provide potential therapeutic strategies in this field. Additionally, certain herbal medicine have demonstrated to be nephrotoxic when incorrectly utilized. Therefore, it is also necessary to investigate the underlying mechanisms contributing to nephrotoxicity of herbal medicine to avoid negative outcomes.
The goal of this Research Topic is to provide a forum to advance research on the molecular and cellular pathway of herbal medicine towards CKD therapies, as well as its safety usage. By focusing and testing on these areas, we can provide further evidence as to the potential use of herbal medicine to treat CKD, and therefore prolonging the survival of patients and reducing the burden of CKD.
• Further improve understanding of the mechanisms, novel molecular and cellular pathways that mediate the therapeutic, or otherwise, actions of herbal medicine
Nephrotoxicity And Chinese Herbal Medicine.
For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.Chronic Kidney failure or chronic renal failure (CRF) or chronic terminal kidney disorder is very common these days with loss of kidney functions. The alteration in kidney functions is visible in the form of swelling on the face and feet, fatigue, muscular weakness, dry, itchy skin. Mainly the diabetes, hypertension, urinary tract obstructions and immunological disorders are the cause of chronic renal failure. The severity of this CRF is graded from stage I to V depending upon the kidney functions.
Best Herbs For Kidney Disease. Hand Drawn Vector Set Of Medicinal Plants.
The kidneys are two bean-shaped organs. Each kidney is about the size of a fist. Healthy kidneys function to remove extra water and wastes, help control blood pressure, keep body chemicals in balance, keep bones strong, tell your body to make red blood cells and help children grow normally. Kidney disease occurs when kidneys are no longer able to clean toxins and waste product from the blood and perform their functions to full capacity. This can happen all of a sudden (Acute) or over time (Chronic). Kidney disease can get worse over time and may lead to kidney failure. If less than 15 percent of your kidney is working normally, that’s considered kidney failure. You may have symptoms from the buildup of waste products and extra water in your body.
Acute Kidney Injury (AKI) is the term that has recently replaced the term ARF. AKI is defined as an abrupt (within hours) decrease in kidney function, which encompasses both injury (structural damage) and impairment (loss of function). It is a syndrome that rarely has a sole and distinct pathophysiology. Many patients with AKI have a mixed aetiology where the presence of sepsis, ischaemia and nephrotoxicity often co-exist and complicate recognition and treatment. Furthermore the syndrome is quite common among patients without critical illness and it is essential that health care professionals, particularly those without specialisation in renal disorders, detect it easily.
Classification of AKI includes pre-renal AKI, acute post-renal obstructive nephropathy and intrinsic acute kidney diseases. Of these, only ‘intrinsic’ AKI represents true kidney disease, while pre-renal and post-renal AKI are the consequence of extra-renal diseases leading to the decreased glomerular filtration rate (GFR). If these pre- and/or post-renal conditions persist, they will eventually evolve to renal cellular damage and hence intrinsic renal disease. (Ref https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198510/)
Four Prescribed Chinese Herbal Medicines Provide Renoprotection And Survival Benefit Without Hyperkalemia Risk In Patients With Advanced Chronic Kidney Disease: A Nationwide Cohort Study
A patient is said to have chronic kidney disease (CKD) if they have abnormalities of kidney function or structure present for more than 3 months. The definition of CKD includes all individuals with markers of kidney damage or those with an eGFR of less than 60 ml/min/1.73m2 on at least 2 occasions 90 days apart (with or without markers of kidney damage).
* Urination changes:- Urine may become foamy or bubbly; urination may be more or less often; amounts of urine may be greater or less than usual; urine color may be more darker or paler than usual; there maybe blood in the urine; urinating may be difficult
* Swelling:- When your kidneys don’t work, excess fluid isn’t removed from your body. It can build up and cause swelling in the legs, ankles, feet, face, and/or hands.
Best Herbs For Kidney Disease
* Fatigue:- The kidneys make a hormone called erythropoietin, or EPO, which tells your body to make oxygen-carrying red blood cells. If your kidneys are damaged, they make less EPO, which means fewer red blood cells are available to carry oxygen. This is called anemia, and itwhich can be treated.
* Metallic Taste in Mouth/Ammonia Breath:- When waste builds up in the blood it is called uremia. This can make food taste different and cause bad breath.
* Shortness of Breath:- Extra fluid in the body can build up in the lungs. This build up, combined with anemia, can result in shortness of breath.
Kidney Failure Herbal Remedies, How To Avoid Dialysis
* Dizziness and Trouble Concentrating:- Due to brain not getting enough oxygen because of anemia, one can feel dizziness, memory and concentration issues.
The kidneys are mentioned as vrikka in Ayurveda. Shotha is the name for swelling. Some books in Ayurveda have mentioned vrikka vicar (kidney disorders) separately while many have elaborately described the shotha vicar its types and effective methods to manage them.
According to Ayurveda urine formation starts in intestine itself although filtration takes place in kidneys. Imbalance of agni (fire element ) disturbs the process of formation and filtration of urine, Malformed urine leads to accumulation of wastes in the body.This unwanted accumulation is known as ‘ama sanchaya’ (toxin accumulation) in Ayurveda. This ‘ama’ accumulation manifests as – loss of appetite, tiredness, heaviness, puffiness around the eyes excess water in the later stages and abnormal values of Creatitnine, Urea ,GFR e.t.c. On the basis of different factors, damage at different levels of filtration apparatus can take place. So, Chronic kidney disease is a condition of the mutravaha srotas (The body channel that is related to the urinary system of the body and its normal functioning). The damage to the tissues is contributed by the imbalance in the three doshas (body humors - Air, Fire and Ether/ Vata, Pitta and Kapha) mainly
0 comments:
Post a Comment